Lagares D. Science Trans Medicine 2017

“Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis” In this study, we have found that the BH3 mimetic drug ABT-263 selectively induces apoptosis (programmed cell death) of scar-forming myofibroblasts from patients with scleroderma, a heterogeneous autoimmune disease characterized by multiorgan fibrosis. In preclinical studies, ABT-263 similarly induces myofibroblast apoptosis and reverses fibrosis in a mouse model of scleroderma."